Molecular mechanisms of translational control
نویسندگان
چکیده
منابع مشابه
Dendritic BC1 RNA in translational control mechanisms
Translational control at the synapse is thought to be a key determinant of neuronal plasticity. How is such control implemented? We report that small untranslated BC1 RNA is a specific effector of translational control both in vitro and in vivo. BC1 RNA, expressed in neurons and germ cells, inhibits a rate-limiting step in the assembly of translation initiation complexes. A translational repres...
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متن کاملFrom factors to mechanisms: translation and translational control in eukaryotes.
Biochemical and genetic studies are revealing a network of interactions between eukaryotic translation initiation factors, further refining or redefining perceptions of their function. The notion of translated mRNA as a 'closed-loop' has gained support from the identification of physical and functional interactions between the two mRNA ends and their associated factors. Translational control me...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2004
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm1488